|
KMID : 0525720150200020078
|
|
Journal of Chitin and Chitosan
2015 Volume.20 No. 2 p.78 ~ p.89
|
|
|
Biomedical Application of Marine Natural Polymers for Cartilage Tissue Regeneration
|
|
Heo Seong-Yeong
Jung Won-Kyo
|
|
|
Abstract
|
|
|
|
Recently, many researchers paid a higher attention on tissue engineering approach that provide physiological and biological substitute to replace tissue loss due to some disease, congenital abnormalities or trauma. For that reason, the development of scaffolding substance for tissue engineering applications has focused on the designing of biomimetic materials that are capable of eliciting specific cellular responses mediated by biomolecular recognition, which can be manipulated by altering design parameters of the material. Marine derived polysaccharide such as alginate, chitosan and hyaluronic acid has demonstrated high biocompatibility, biodegradability, non-toxicity and low chronic inflammatory response. Therefore, these materials can applicable tissue engineering application. Among them, alginate is a well-known biomaterial obtained from brown macroalgae and is widely used in biomedical, drug delivery and tissue engineering application. Moreover, since marine organism derived materials have not yet been reported with bovine spongiform encephalopathy, transmissible spongiform encephalopathy and foot and mouth disease compared to land animals. In light of the various proven, this review focuses on tissue regenerative properties of natural polysaccharides derived from marine organisms for cartilage tissue regeneration application.
|
|
|
KEYWORD
|
|
|
Marine organisms, Alginate, Chitosan, Hyaluronic acid, Agarose, Cartilage tissue engineering
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|
|